Director Shareholding

GlaxoSmithKline PLC
21 March 2003




                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



19 March 2003              Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ('the GSK Trust'),
                           sold 4,674 Ordinary Shares in the Company at a price
                           of £11.885 per Ordinary Share.

                           Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ('the GSK Trust'),
                           transferred 6,986 Ordinary Shares in the Company on
                           behalf of participants of the Glaxo Wellcome 1999
                           Long Term Incentive Plan.


The Company was advised of this transaction on 20 March 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


21 March 2003


                      This information is provided by RNS
            The company news service from the London Stock Exchange