Director Shareholding

GlaxoSmithKline PLC
25 July 2003






                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

24 July 2003               Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           transferred 2,804 Ordinary Shares in the Company to
                           participants in the SmithKline Beecham Employee Share
                           Option Plan 1991.

24 July 2003               Abacus (GSK) Trustees Limited, as trustee of the GSK
                           Trust, sold 4,241 Ordinary Shares in the Company on
                           behalf of a participant in the Glaxo Wellcome 1999
                           Long Term Incentive Plan at a price of £12.15 per
                           Ordinary share.

24 July 2003               Abacus (GSK) Trustees Limited, as trustee of the GSK
                           Trust, sold 1,361 Ordinary Shares in the Company on
                           behalf of a participant in the Glaxo Wellcome 1999
                           Long Term Incentive Plan at a price of £12.16 per
                           Ordinary share.

24 July 2003               Abacus (GSK) Trustees Limited, as trustee of the GSK
                           Trust, sold 432 Ordinary Shares in the Company on
                           behalf of a participant in the SmithKline Beecham Mid
                           Term Incentive Plan at a price of £12.22612 per
                           Ordinary share.


The Company was advised of these transactions on 25 July 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


S M Bicknell

Company Secretary


25 July 2003


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