Director Shareholding

GlaxoSmithKline PLC
04 August 2003




                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


31 July 2003               Abacus (GSK) Trustees Limited, as trustee of the
                           GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                           transferred 3,158 Ordinary Shares in the Company on
                           behalf of participants in the Glaxo Wellcome
                           International Share Option Plan.
31 July 2003               The GSK Trust transferred 3,519 Ordinary Shares in
                           the Company on behalf of participants in the Glaxo
                           Group Option Plan.
31 July 2003               The GSK Trust sold 4,050 Ordinary Shares in the
                           Company on behalf of participants in the SmithKline
                           Beecham Mid Term Incentive Plan at a price of £11.86
                           per share.
31 July 2003               The GSK Trust transferred 10,310 Ordinary Shares in
                           the Company on behalf of participants in the
                           SmithKline Beecham Mid Term Incentive Plan.
31 July 2003               The GSK Trust transferred 22,038 Ordinary Shares in
                           the Company to participants in the SmithKline
                           Beecham Employee Share Option Plan 1991.
1 August 2003              The GSK Trust transferred 3,022 Ordinary Shares in
                           the Company to participants in the SmithKline
                           Beecham Employee Share Option Plan 1991.




The Company was advised of these transactions on 1 August 2003 and 4 August
2003.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.

S M Bicknell

Company Secretary

4 August 2003


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