Director Shareholding

GlaxoSmithKline PLC
22 September 2003


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

19 September 2003         The Administrators of the SmithKline Beecham Employee
                          Benefit Trust ("the Trust") notified the Company on 22
                          September 2003 that 17,503 Ordinary shares had been
                          transferred from the Trust to participants in the
                          SmithKline Beecham Bonus Investment Plan.

The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell

Company Secretary


22 September 2003


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