Director Shareholding

GlaxoSmithKline PLC
24 November 2003

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



21 November 2003             The Administrators of the SmithKline Beecham Employee
                             Benefit Trust ("the Trust") notified the Company on 24
                             November 2003 that 565 Ordinary shares had been
                             transferred from the Trust to a participant in the
                             SmithKline Beecham Bonus Investment Plan.

                             The Administrators of the Trust notified the Company on
                             24 November 2003 that 8,297 Ordinary shares had been
                             transferred from the Trust to participants in the
                             GlaxoSmithKline Annual Investment Plan.




The Trust is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and John Coombe are therefore interested in
the shares held in the fund from time to time in the same way as other employees
or former employees of GlaxoSmithKline plc and its subsidiaries.




S M Bicknell

Company Secretary


24 November 2003


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