Director Shareholding

GlaxoSmithKline PLC
19 December 2003


                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary and
American Depositary Shares of GlaxoSmithKline plc.



19 December 2003             Abacus (GSK) Trustees Limited, as trustee of the
                             GlaxoSmithKline Employee Trust, ("GSK Trust"),
                             converted 999,000 Ordinary shares in the Company
                             into 499,500 ADSs in the Company which were
                             subsequently sold at a price of US$45.23 per ADS.

                             Abacus Corporate Trustee Limited, as trustee of the
                             GlaxoSmithKline US Trust, ("the GSK US Trust"),
                             purchased 499,500 American Depositary Shares (ADSs)
                             in the Company at a price of US$45.23 per ADS.

18 December 2003             Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, transferred 7,727 Ordinary Shares in the
                             Company to participants in the SmithKline Beecham
                             Employee Share Option Plan 1991.




The Company was advised of these transactions on 19 December 2003.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Mr J D Coombe
are therefore interested in the shares held in the GSK Trust from time to time
in the same way as other employees or former employees of GlaxoSmithKline plc
and its subsidiaries.


The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries. One of the Company's directors, Dr J-P Garnier is therefore
interested in the shares held in the GSK US Trust from time to time in the same
way as other employees or former employees of SmithKline Beecham Corporation and
its subsidiaries.


S M Bicknell

Company Secretary


19 December 2003


                      This information is provided by RNS
            The company news service from the London Stock Exchange                JBBBJ