Director Shareholding

GlaxoSmithKline PLC
13 February 2004


                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


12 February 2004             Abacus (GSK) Trustees Limited, as trustee of the
                             GlaxoSmithKline Employee Trust, ("GSK Trust"), sold
                             121,727 Ordinary shares in the Company on behalf of
                             participants in the GlaxoSmithKline Performance
                             Share Plan at a price of £11.07 per share.

12 February 2004             Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, converted 98,514 Ordinary shares in the
                             Company to 49,257 ADSs in the Company which were
                             subsequently sold on behalf of participants in the
                             GlaxoSmithKline Performance Share Plan at a price
                             of US$43.2492 per ADS.

12 February 2004             Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, transferred 1,611 Ordinary shares in the
                             Company to participants in the SmithKline Beecham
                             Employee Share Option Plan 1991.


The Company was advised of these transactions on 13 February 2004.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary

13 February 2004


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