Director Shareholding

GlaxoSmithKline PLC
19 February 2004




                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



18 February 2004             Abacus (GSK) Trustees Limited, as trustee of the
                             GlaxoSmithKline Employee Trust, ("GSK Trust"), sold
                             1,133 Ordinary Shares in the Company on behalf of
                             participants in the SmithKline Beecham Mid-Term
                             Incentive Plan at a price of £11.0026.

                             Abacus (GSK) Trustees Limited, as trustee of the
                             GSK Trust, transferred 2,691 Ordinary Shares in the
                             Company to participants of the SmithKline Beecham
                             Mid-Term Incentive Plan.


The Company was advised of these transactions on 19 February 2004.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell

Company Secretary

19 February 2004


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