Director Shareholding

GlaxoSmithKline PLC
16 April 2004



                              Directors Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £11.45 per Ordinary Share on 15 April
2004 through the Company's ShareReward Plan ("the Plan") which Mr Coombe entered
on 5 October 2001:



Mr J D Coombe                      Acquisition of 6 Ordinary Shares under the 
                                   Dividend Reinvestment element of the Plan

Mr Coombe and the Company were advised of this information on 16 April 2004.






S M Bicknell

Company Secretary


16 April 2004


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