Director Shareholding

GlaxoSmithKline PLC
22 March 2004

                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



19 March 2004      The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                   Trust") notified the Company on 22 March 2004 that 2,907 Ordinary shares
                   had been transferred from the Trust to a participant in the SmithKline
                   Beecham Bonus Investment Plan.

                   The Administrators of the Trust also notified the Company on 22 March 2004
                   that 338,386 Ordinary shares had been purchased on behalf of participants
                   in the GlaxoSmithKline Annual Investment Plan at a price of £10.66 per
                   share.




The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.


S M Bicknell
Company Secretary

22 March 2004



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