Director Shareholding

GlaxoSmithKline PLC
10 March 2004



                              Director's Interests



I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £11.08 per Ordinary Share on 9 March
2004 through the Company's ShareReward Plan ("the Plan") which Mr Coombe entered
on 5 October 2001:



Mr J D Coombe    Acquisition of 11 Ordinary Shares under the partnership element 
                 of the Plan (personal contribution)

                 Acquisition of 11 Ordinary Shares under the matching element of 
                 the Plan (Company contribution)

Mr Coombe and the Company were advised of this information on 10 March 2004.


S M Bicknell
Company Secretary

10 March 2004


                      This information is provided by RNS
            The company news service from the London Stock Exchange