Director Shareholding

GlaxoSmithKline PLC
10 June 2004


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


21 May 2004         Abacus (GSK) Trustees Limited, as trustee of the
                    GlaxoSmithKline Employee Trust, ("GSK Trust"), transferred
                    4,828 Ordinary Shares in the Company to participants in the
                    SmithKline Beecham Employee Share Option Plan 1991.


9 June 2004         Abacus (GSK) Trustees Limited, as trustee of the GSK Trust,
                    transferred 12,379 Ordinary Shares in the Company to
                    participants in the SmithKline Beecham Employee Share Option
                    Plan 1991.

The Company was advised of these transactions on 10 June 2004.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

S M Bicknell
Company Secretary
10 June 2004


                      This information is provided by RNS
            The company news service from the London Stock Exchange