Director Shareholding

GlaxoSmithKline PLC
01 June 2004



                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




26 May 2004        Abacus (GSK) Trustees Limited, as trustee of the
                   GlaxoSmithKline Employee Trust, ("GSK Trust"), transferred
                   49,406 Ordinary Shares in the Company to participants in the
                   SmithKline Beecham Employee Share Option Plan 1991.


27 May 2004        Abacus (GSK) Trustees Limited, as trustee of the GSK Trust,
                   transferred 25,580 Ordinary Shares in the Company to
                   participants in the SmithKline Beecham Employee Share Option
                   Plan 1991.





The Company was advised of these transactions on 28 May 2004.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



S M Bicknell
Company Secretary
1 June 2004


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