Director Shareholding

GlaxoSmithKline PLC
09 July 2004




                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




7 July 2004        Abacus (GSK) Trustees Limited, as trustee of the
                   GlaxoSmithKline Employee Trust, ("GSK Trust"), transferred
                   1,818 Ordinary Shares in the Company to participants in the
                   SmithKline Beecham Employee Share Option Plan 1991.





The Company was advised of this transaction on 8 July 2004.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



S M Bicknell

Company Secretary

9 July 2004


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