Director Shareholding

GlaxoSmithKline PLC
05 October 2004


                              Director's Interests

I give below details of changes in interests in the Ordinary Share ADRs of
GlaxoSmithKline plc in respect of the under-mentioned director:-


Dr J P Garnier      The Administrators of the SmithKline Beecham Mid-Term 
                    Incentive Plan notified the Company and Dr Garnier on 4 
                    October 2004 that he had increased his interest by 1,356.151 
                    Ordinary Share ADRs at a price of $43.650 per Ordinary Share 
                    ADR following the re-investment of the dividend paid to 
                    shareholders on 30 September 2004.



S M Bicknell
Company Secretary

5 October 2004


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