Director Shareholding

GlaxoSmithKline PLC
09 September 2004


                                Director's Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


9 September 2004    The Administrators of the SmithKline Beecham Employee 
                    Benefit Trust ("the Trust") notified the Company on 9 
                    September 2004 that 11,821 Ordinary shares had been 
                    transferred from the Trust to participants in the 
                    GlaxoSmithKline Annual Investment Plan.

                    The Administrators of the Trust notified the Company on 9 
                    September 2004 that 59 Ordinary shares had been transferred 
                    from the Trust to participants in the SmithKline Beecham 
                    Bonus Investment Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.


S M Bicknell
Company Secretary

9 September 2004



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