Director Shareholding

GlaxoSmithKline PLC
05 November 2004




                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:

              The Administrators of the GlaxoSmithKline US Retirement 
              Savings Plan ("the Plan") notified GlaxoSmithKline plc 
              on 05 November 2004, that as a result of a movement in 
              the fund on 04 November 2004, the number of Ordinary 
              Share ADRs held by the fund had changed from 18,880,103 
              to 18,906,115 at an average price of $44.37

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.





S M Bicknell
Company Secretary



05 November 2004


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