Director Shareholding

GlaxoSmithKline PLC
12 November 2004

                              Director's Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned Director arising from the
purchase of Ordinary Shares at a price of £11.80 per Ordinary Share on 9
November 2004 through the Company's ShareReward Plan ("the Plan") which Mr
Coombe entered on 5 October 2001:


Mr J D Coombe      Acquisition of 11 Ordinary Shares under the partnership 
                   element of the Plan (personal contribution)

                   Acquisition of 11 Ordinary Shares under the matching element 
                   of the Plan (Company contribution)

Mr Coombe and the Company were advised of this information on 12 November 2004.




S M Bicknell
Company Secretary

12 November 2004


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