Director Shareholding

GlaxoSmithKline PLC
07 December 2004



Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:


The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the
Plan") notified GlaxoSmithKline plc on 6 December 2004, that as a result of a
movement in the fund on 3 December 2004, the number of Ordinary Share ADRs held
by the fund had changed from 18,804,786 to 18,841,944 at an average price of
$43.73


The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.





S M Bicknell
Company Secretary

7 December 2004


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