Director Shareholding

GlaxoSmithKline PLC
05 November 2004


                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


04 November 2004          Abacus (GSK) Trustees Limited, as trustee of the
                          GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                          transferred 38,664 Ordinary Shares in the Company to  
                          participants in the SmithKline Beecham Employee Share 
                          Option Plan 1991.


The Company was advised of these transactions on 05 November 2004.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary

05 November 2004




                      This information is provided by RNS
            The company news service from the London Stock Exchange