Director Shareholding

GlaxoSmithKline PLC
31 January 2005

Director's Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

27 January 2005            The Administrators of the SmithKline Beecham Employee 
                           Benefit Trust notified the Company on 31 January 2005 
                           that 1806 Ordinary shares in the Company had been 
                           sold on 27 January 2005 on behalf of a participant in 
                           the SmithKline Beecham Bonus Investment Plan at a 
                           price of £11.71.

                           The Trust also notified the Company on 31 January 
                           2005 that 2,588 Ordinary shares had been transferred 
                           from the Trust to a participant in the SmithKline
                           Beecham Bonus Investment Plan.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

S M Bicknell
Company Secretary

31 January 2005




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