Director Shareholding

GlaxoSmithKline PLC 09 December 2004 Directors' Interests I give below details of changes in directors' interests in the Ordinary and American Depositary Shares of GlaxoSmithKline plc. 07 December 2004 Abacus (GSK) Trustees Limited, as trustee of the GSK Trust, transferred 12,648 Ordinary Shares in the Company to participants in the SmithKline Beecham Employee Share Option Plan 1991. 08 December 2004 Abacus (GSK) Trustees Limited, as trustee of the GlaxoSmithKline Employee Trust, ("GSK Trust"), converted 9,791,588 Ordinary shares in the Company into 4,895,794 ADSs in the Company which were subsequently sold at a price of US$43.73 per ADS. Abacus Corporate Trustee Limited, as trustee of the GlaxoSmithKline US Trust, ("the GSK US Trust"), purchased 4,895,794 American Depositary Shares (ADSs) in the Company at a price of US$43.73 per ADS. The Company was advised of these transactions on 08 December 2004. The GSK Trust is a discretionary trust of which all employees or former employees of GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and Mr J D Coombe are therefore interested in the shares held in the GSK Trust from time to time in the same way as other employees or former employees of GlaxoSmithKline plc and its subsidiaries. The GSK US Trust is a grantor trust of which all employees or former employees of SmithKline Beecham Corporation and its subsidiaries are potential beneficiaries. Two of the Company's directors, Dr J-P Garnier and Dr T Yamada are therefore interested in the shares held in the GSK US Trust from time to time in the same way as other employees or former employees of SmithKline Beecham Corporation and its subsidiaries. S M Bicknell Company Secretary 09 December 2004 This information is provided by RNS The company news service from the London Stock Exchange

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GSK (GSK)
UK 100

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