Director Shareholding

GlaxoSmithKline PLC
30 March 2005






                              Directors' Interests


I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned director:



Mr J D Coombe acquired a  beneficial interest in 9 Ordinary Shares purchased
under a Personal Equity Plan on 29 March 2005 at £12.27.


Mrs G A Coombe (wife of Mr J D Coombe) acquired a beneficial interest in 7
Ordinary Shares purchased under a Personal Equity Plan on 29 March 2005 at
£12.27.



The Director and the Company were advised of these transactions on 30 March
2005.




S M Bicknell

Company Secretary



30 March 2005




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