Director Shareholding

GlaxoSmithKline PLC 21 March 2005 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 18 March 2005 The Administrators of the SmithKline Beecham Employee Benefit Trust ("the Trust") notified the Company on the 21 March 2005 that 256,018 Ordinary shares had been purchased for participants in the SmithKline Beecham Annual Investment Plan at a price of £12.25 per share. The Trust is a discretionary fund of which all non US employees or former employees of GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. One of the Company's directors, John Coombe is therefore interested in the shares held in the fund from time to time in the same way as other non US employees or former employees of GlaxoSmithKline plc and its subsidiaries. S M Bicknell Company Secretary 21 March 2005 This information is provided by RNS The company news service from the London Stock Exchange

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