Director Shareholding

GlaxoSmithKline PLC
22 April 2005



                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


20 April 2005                 Abacus (GSK) Trustees Limited ("the Trustees"), as trustee of
                              the GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                              transferred 7,141 Ordinary Shares in the Company to
                              participants in the GlaxoSmithKline Performance Share Plan.


21 April 2005                 The Trustees also transferred 1,638 Ordinary Shares in the
                              Company to participants in the SmithKline Beecham Employee
                              Share Option Plan 1991.


The Company was advised of these transactions on 22 April 2005.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop, are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



S M Bicknell
Company Secretary


22 March 2005






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