Director Shareholding

GlaxoSmithKline PLC
25 April 2005



Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:


     The Administrators of the GlaxoSmithKline US Retirement Savings Plan 
     ("the Plan") notified GlaxoSmithKline plc on 25 April 2005, that as a 
     result of a movement in the fund on 21 April 2005, the number of Ordinary 
     Share ADRs held by the fund had changed from 18,308,664 to 18,260,668 at 
     an average price of $47.50



The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.




S M Bicknell
Company Secretary


25 April 2005


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