Holding(s) in Company

GlaxoSmithKline PLC
22 April 2005



GLAXOSMITHKLINE plc - Notification of Major Interests in Shares



GlaxoSmithKline plc (the Company) today received notification from Barclays plc
in compliance with Part VI of the Companies Act 1985 (as amended), that on 19
April 2005 it had the following interests in the Company's Ordinary Shares of 25
pence:


Registered Holder                                           Current shareholding
Barclays Global Fund Advisors                                         13,253,408
Barclays Life Assurance Co Ltd                                         8,626,453
Barclays Private Bank and Trust Ltd                                        1,000
Barclays Private Bank and Trust Ltd                                      263,209
Barclays Global Investors Ltd                                        101,177,016
Barclays Capital Securities Ltd                                       14,738,560
Gerrard Ltd                                                            1,967,555
Barclays Bank Trust Company Ltd                                          936,168
Barclays Capital Inc                                                   1,013,600
Barclays Global Investors Japan Ltd                                    4,674,267
Barclays Private Bank Ltd                                              1,784,812
Barclays Global Investors Australia Ltd                                2,207,508
Barclays Global Investors Japan Trust & Banking                        7,439,862
Barclays Global Investors, N.A.                                       70,384,330
Barclays Private Bank & Trust Ltd                                         11,495
TOTAL                                                                228,479,243



Barclays plc's total holding has decreased from 4.14 per cent to 3.9 per cent of
the issued share capital of the Company (excluding shares held in Treasury).


S M Bicknell
Company Secretary


22 April 2005




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