Holding(s) in Company

Intl. Biotechnology Trust PLC
20 February 2003


20 February 2003

                    Substantial Share Interest Notification


We are writing to advise that the Company was notified on 20 February 2003 that
Deutsche Bank AG and its subsidiary companies have a notifiable interest in
2,500,000 ordinary shares of 25p each, representing 5.14% of the 48,615,467
shares in issue.


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Enquiries:


John Spedding

Schroder Investment Management Limited            020 7658 3206










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