Director Shareholding

Phytopharm PLC
1 December 2000

                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

    PHYTOPHARM PLC

2)  NAME OF DIRECTOR

    Dr RICHARD DIXEY

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    AS 2

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

    AS 2

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary



7)  Number of shares/amount of
    stock acquired



8)   (N/A %)
    of issued Class


9)  Number of shares/amount
    of stock disposed



10)  ( N/A %)
    of issued Class


11) Class of security




12) Price per share



13) Date of transaction



14) Date company informed



15) Total holding following this notification



16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant

    30 NOVEMBER 2000

18) Period during which or date on which exercisable

    17,110 - 1 DEC 2003 TO 30 NOV 2007
    17,110 - 1 DEC 2005 - 30 NOV 2007

19) Total amount paid (if any) for grant of the option

    NIL

20) Description of shares or debentures involved: class, number.

    34,220 ORDINARY 1 pence

21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise

    £6.575

22) Total number of shares or debentures over which options held
    following this notification

    483,963 

23) Any additional information



24) Name of contact and telephone number for queries

    S LOACH  -  01480-437697

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification    1 DECEMBER 2000                             



                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

    PHYTOPHARM PLC

2)  NAME OF DIRECTOR

    Ms JAYNE ALLAN

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    AS 2

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

    AS 2

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary



7)  Number of shares/amount of
    stock acquired



8)   (N/A %)
    of issued Class


9)  Number of shares/amount
    of stock disposed



10)  ( N/A %)
    of issued Class


11) Class of security




12) Price per share



13) Date of transaction



14) Date company informed



15) Total holding following this notification



16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant

    30 NOVEMBER 2000

18) Period during which or date on which exercisable

    4,038 - 1 DEC 2003 TO 30 NOV 2007
    7,984 - 1 DEC 2005 - 30 NOV 2007

19) Total amount paid (if any) for grant of the option

    NIL

20) Description of shares or debentures involved: class, number.

    12,022 ORDINARY 1 pence

21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise

    £6.575

22) Total number of shares or debentures over which options held
    following this notification

    208,000

23) Any additional information



24) Name of contact and telephone number for queries

    S LOACH  -  01480-437697

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification    1 DECEMBER 2000                             




                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

    PHYTOPHARM PLC

2)  NAME OF DIRECTOR

    Dr SIMON LOACH

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    AS 2

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

    AS 2

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary



7)  Number of shares/amount of
    stock acquired



8)   (N/A %)
    of issued Class


9)  Number of shares/amount
    of stock disposed



10)  ( N/A %)
    of issued Class


11) Class of security




12) Price per share



13) Date of transaction



14) Date company informed



15) Total holding following this notification



16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant

    30 NOVEMBER 2000

18) Period during which or date on which exercisable

    3,036 - 1 DEC 2003 TO 30 NOV 2007
    3,036 - 1 DEC 2005 - 30 NOV 2007

19) Total amount paid (if any) for grant of the option

    NIL

20) Description of shares or debentures involved: class, number.

    6,072 ORDINARY 1 pence

21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise

    £6.575

22) Total number of shares or debentures over which options held
    following this notification

    435,276

23) Any additional information



24) Name of contact and telephone number for queries

    S LOACH  -  01480-437697

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification    1 DECEMBER 2000                             


                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

    PHYTOPHARM PLC

2)  NAME OF DIRECTOR

    Dr DARYL REES

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    AS 2

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

    AS 2

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary



7)  Number of shares/amount of
    stock acquired



8)   (N/A %)
    of issued Class


9)  Number of shares/amount
    of stock disposed



10)  ( N/A %)
    of issued Class


11) Class of security




12) Price per share



13) Date of transaction



14) Date company informed



15) Total holding following this notification



16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant

    30 NOVEMBER 2000

18) Period during which or date on which exercisable

    11,407 - 1 DEC 2003 TO 30 NOV 2007
    11,406 - 1 DEC 2005 - 30 NOV 2007

19) Total amount paid (if any) for grant of the option

    NIL

20) Description of shares or debentures involved: class, number.

    22,813 ORDINARY 1 pence

21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise

    £6.575

22) Total number of shares or debentures over which options held
    following this notification

    142,813

23) Any additional information



24) Name of contact and telephone number for queries

    S LOACH  -  01480-437697

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification    1 DECEMBER 2000