Holding(s) in Company

Phytopharm PLC
19 August 2003

Re: Notification of Major Interests in Shares


The Company received notification on 13 August from AMVESCAP PLC that AMVESCAP's
overall holding has remained at 26%, as disclosed on 2 June 2003, following
transfers between funds under its management. The notifiable change in holdings
is that on 8 August 2003, INVESCO Perpetual Income Fund sold 310,000 shares and
now holds 3,869,362 shares (9.98%) registered in the name of Vidacos Nominees
Limited.

AMVESCAP's current aggregate holding is 10,240,862 shares (26.41%). 





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