Holding(s) in Company

Phytopharm PLC
27 November 2003

Re: Notification of Major Interests in Shares

The Company received notification on 27th November 2003 from AMVESCAP PLC 
concerning the realignment of interests in the Company's shares. Following the 
recent conversion of unit trusts to ICVCs, AMVESCAP ceased to be interested, 
within the meaning of Sections 203 and 208 of the Act, in 6,238,803 ordinary 
shares. Immediately following this transaction, AMVESCAP had a notifiable 
interest in 4,002,059 (10.3%) shares.  The breakdown of AMVESCAP's registered 
holders are set out below:

Registered Holder                                  Number of Shares

Bank of New York Nominees Limited                           618,918 
Chase Nominees Limited                                      342,000 
Vidacos Nominees Limited                                  1,309,764 
HSBC Nominees Limited                                     1,514,427 
Northern Trust Nominees Limited                             210,000 
CM Investment Nominees Limited                                6,950

Immediately following the same transaction, the ICVC and registered holder named 
below had a notifiable interest in the following number of shares:

ICVC                        Registered Holder     Number of Shares        %

INVESCO Perpetual UK        Vidacos Nominees             5,406,647     13.9 
Investment Series           Limited

AMVESCAP's aggregate holding remains unchanged at 10,240,862 shares (26.4%) as 
disclosed on 2 June 2003, following transfers between the funds under its 
management.
 

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