Blocklisting Interim Review

Oxford Biomedica PLC
22 November 2005


                        BLOCKLISTING SIX MONTHLY RETURN

    INFORMATION PROVIDED ON THIS FORM MUST BE TYPED OR PRINTED ELECTRONICALLY.


To:       The FSA

Date:     21 November 2005   


1. Name of applicant:               Oxford Biomedica plc

2. Name of scheme                   Oxford Biomedica Share Option Scheme

3. Period of return:                From    20 May 2005   To    18 November 2005 


4. Balance under scheme from 
   previous return:                 11,145,379

5. The amount by which the block 
   scheme has been increased, if 
   the scheme has been increased 
   since the date of the last 
   return:                          -

6. Number of securities issued/
   allotted under scheme during 
   period:                          2,940,089


7. Balance under scheme not yet 
   issued / allotted at end of 
   period                           8,205,290


8. Number and class of 
   securities originally listed     17,383,143 ordinary shares of 1p each on 
   and the date of admission        9 May 2001

9. Total number of securities in 
   issue at the end of the period   378,110,169


Name of contact                     Andrew Wood


Address of contact                  Oxford Biomedica plc
                                    Medawar Centre
                                    Oxford Science Park
                                    Oxford
                                    OX4 4GA

Telephone number of contact         01865 783 000


Signed by     Andrew Wood
              Chief Financial Officer, for and on behalf of

              Oxford Biomedica plc
              Name of applicant
              

If you knowingly or recklessly give false or misleading information you may be
liable to prosecution.



                      This information is provided by RNS
            The company news service from the London Stock Exchange