Director/PDMR Shareholding

Oxford Biomedica PLC
15 December 2005


                      Oxford BioMedica plc ('the Company')

                            Directors' Shareholdings

Following the completion of the Company's Placing, Open Offer and Subscription
which occurred today, the Company has today been notified by those Directors of
the Company whose respective holdings in ordinary shares of 1p in the Company
('Ordinary Shares') has increased as a result of taking up their entitlement to
Ordinary Shares under the Open Offer as follows:

Director               Increase in              Resultant            % of issued
                   Ordinary Shares            holdings of        share capital
                                          Ordinary Shares

P.J. Nolan                 2,000                149,738                   0.03
N.L. Woolf                11,000                165,000                   0.03
P.N Rodgers               12,000                 22,000                   0.00
R.Uppal 1                 11,000                165,000                   0.03

1.       These Ordinary Shares are held in a self-invested pension plan

15 December 2005



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