Director/PDMR Shareholding

Oxford Biomedica PLC
16 December 2005


           Oxford BioMedica plc ('the Company'or 'Oxford BioMedica')

                            Directors' Shareholdings

The Company today announces that on the 15 December 2005 it granted share
options over ordinary shares of 1 pence each in the Company ('share options') to
certain directors, under the Oxford BioMedica 1996 (No.1) share option scheme
('the Scheme'). The exercise price for each of the options is 29 pence per share
and no payment was made in respect of the grant of these share options.

Under the Scheme, the new share options may be exercised between 15 December
2008 and 15 December 2012. However, if at the time of exercise, or for at least
12 months in the three years before exercise, the percentage increase in Oxford
BioMedica's total shareholder return exceeds the percentage increase in the FTSE
TechMark Mediscience index since the date of the grant of the share option.

                                        New share options to be granted
Professor Alan Kingsman                            208,000
Professor Susan Kingsman                           170,000
Peter Nolan                                        153,000
Andrew Wood                                        193,000
Nick Woolf                                         153,000

Following the grant of these share options, the interests of these directors in
options over ordinary shares of 1 pence each in the Company are:

                                        New share options to be granted
Professor Alan Kingsman                            578,000
Professor Susan Kingsman                           475,000
Peter Nolan                                        883,028
Andrew Wood                                      1,258,891
Nick Woolf                                       1,086,124


Andrew Wood
Company Secretary, Oxford BioMedica plc
Tel. [phone]
16 December 2005




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