Holding(s) in Company

Oxford Biomedica PLC
20 February 2007


TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Identity of the issuer or the underlying issuer of existing shares to which
   voting rights are attached (ii):

   Oxford BioMedica PLC

2. Reason for the notification (please state Yes/No): ( )

   An acquisition or disposal of voting rights: (Yes)

   An acquisition or disposal of financial instruments which may result in the
   acquisition of shares already issued to which voting rights are attached: ( )

   An event changing the breakdown of voting rights: ( )

   Other (please specify) : ( )

3. Full name of person(s) subject to the notification obligation (iii):

   Barclays plc

4. Full name of shareholder(s) (if different from 3.) (iv):

   Barclays Capital Securities Ltd
   Barclays Global Investors Ltd
   Barclays Life Assurance Co Ltd
   Barclays Private Bank and Trust Ltd
   Barclays Stockbrokers Ltd
   Gerrard Ltd

5. Date of the transaction (and date on which the threshold is crossed or
   reached if different) (v):

   16 February 2007

6. Date on which issuer notified:

   19 February 2007

7. Threshold(s) that is/are crossed or reached:

   6% to 5%

8. Notified details:

A: Voting rights attached to shares

Class/type of shares       Situation previous to the Triggering transaction (vi)
if possible using                          
the ISIN CODE              Number of shares       Number of voting Rights (viii)
GB0006648157                30,117,945                      30,117,945

Resulting situation after the triggering transaction (vii)
Class/type of shares       Number of             Number of              % of voting rights
if possible using             shares    voting rights (ix)         
the ISIN CODE
                              Direct            Direct (x) Indirect (xi)   Direct Indirect
                                                         
GB0006648157                29,868,965                   -    29,868,965        -    5.95%


B: Financial Instruments

Resulting situation after the triggering transaction (xii)
Type of     Expiration Date  Exercise/Conversion    Number of voting  % of voting
financial            (xiii)    Period/Date (xiv)  rights that may be       rights
instrument                                           acquired if the
                                                       instrument is
                                                          exercised/
                                                          converted.
N/A                    N/A                  N/A                  N/A          N/A


Total (A+B)
Number of voting rights  % of voting rights
             29,868,965               5.95%

9. Chain of controlled undertakings through which the voting rights and/or the
   financial instruments are effectively held, if applicable (xv):

               Registered Holder                            Holding        %

Barclays plc                                             29,868,965    5.95%
               Barclays Capital Securities Ltd
               Barclays Global Investors Ltd
               Barclays Life Assurance Co Ltd
               Barclays Private Bank and Trust Ltd
               Barclays Stockbrokers Ltd
               Gerrard Ltd

Proxy Voting:

10. Name of the proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

None

14. Contact name:

Andrew Wood


15. Contact telephone number:

01865 783000

Annex to Notification Of Major Interests In Shares (xvi)


A: Identity of the person or legal entity subject to the notification obligation

Full name (including legal form for legal entities):
Barclays plc

Contact address (registered office for legal entities):
1 Churchill Place, London, E14 5HP

Phone number:
020 7116 2913

Other useful information (at least legal representative for legal persons):
N/A

B: Identity of the notifier, if applicable (xvii)

Full name:
Geoff Smith

Contact address:
Barclays Compliance
1 Churchill Place, London, E14 5HP

Phone number:
020 7116 2913



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