Major Interest in Shares

Oxford Biomedica PLC
10 December 2007


For Immediate Release                                           10 December 2007
                                                                            


                                Oxford BioMedica

                           Major Interests in Shares



1. Identity of the issuer or the underlying issuer of existingshares to which 
   voting rights are attached 

   Oxford Biomedica Plc
                                           
2. Reason for notification (yes/no)                                                                    

   An acquisition or disposal of voting rights                             Yes                         

3. Full name of person(s) subject to notification obligation:      

   Credit Agricole Cheuvreux International Ltd

4. Full name of shareholder(s) (if different from 3):        

   Credit Agricole Cheuvreux International Ltd CAAM
                                          
           
5. Date of transaction (and date on which the threshold is crossed or reached if  
   different):

   05/12/07

6. Date on which issuer notified:         

   07/12/07

7. Threshold(s) that is/are crossed or reached:                                  

   Holding after transaction went through percentage threshold


8: Notified Details
   A: Voting rights attached to shares
Class/type   Situation previous to the   Resulting situation after the triggering transaction
of shares    triggering transaction
If possible
use ISIN
code
GB0006648157
             Number of     Number of     Number of     Number of voting       Percentage of
             shares        voting rights shares        rights                 voting rights

              42,798,851    42,798,851    42,698,851
                                                        42,698,851   Indirect Direct  Indirect
                                                                               7.99%
Total (A+B)
Number of voting rights              Percentage of voting rights

      42,698,851                                   7.99%



9. Chain of controlled undertakings through which the voting rights and /or the
   financial instruments are effectively held, if applicable:


SAS Rue La Boetie
Credit Agricole SA
Calyon SA
CAAM
Credit Agricole Cheuvreux SA 42,698,851 7.99%


Proxy Voting:

10. Name of proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14 Contact name:                                       Andrew Wood

15. Contact telephone name:                            01865 783000






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