Major Interest in Shares

Oxford Biomedica PLC
23 January 2008


For Immediate Release                                            23 January 2008

                              Oxford BioMedica plc


TR - 1:       NOTIFICATION OF MAJOR INTERESTS IN SHARES


1.     Identity of the issuer or the underlying issuer of existing shares to
       which voting rights are attached:

       Oxford BioMedica plc

2.     Reason for the notification (please tick the appropriate box or boxes):

       An acquisition or disposal of voting rights

3.     Full name of person(s) subject to the notification obligation:

       Prudential plc group of companies

4.     Full name of shareholder(s) (if different from 3.)

               Registered Holder                       Holding      %

Prudential plc Total Notifiable Interest               59,254,839   11.03%
               Norturst Nominee Ltd A/C MHF01          134,616
               Nortrust Nominee Ltd A/C MKK01          33,000,000
               Nortrust Noms Ltd                       124,000
               PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC         7,254,855

M&G Group Limited                                      59,254,839   11.03%
               Norturst Nominee Ltd A/C MHF01          134,616
               Nortrust Nominee Ltd A/C MKK01          33,000,000
               Nortrust Noms Ltd                       124,000
               PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC         7,245,855

M&G Investment Management Limited                      59,120,223   11.00%
               Nortrust Nominee Ltd A/C MKK01          33,000,000
               Nortrust Noms Ltd                       124,000
               PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC         7,245,855
M&G Limited                                            59,254,839   11.03%
               Norturst Nominee Ltd A/C MHF01          134,616
               Nortrust Nominee Ltd A/C MKK01          33,000,000
               Nortrust Noms Ltd                       124,000
               PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC         7,245,855

M&G Securities Limited                                 33,134,616   6.17%
               Norturst Nominee Ltd A/C MHF01          134,616
               Nortrust Nominee Ltd A/C MKK01          33,000,000

The Prudential Assurance Company Limited               25,996,223   4.84%
               PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
               PRUCLT HSBC GIS NOM (UK) PPL AC         7,245,855



5.     Date of the transaction and date on which the threshold is crossed or
       reached:

       January 18, 2008

6.     Date on which issuer notified:

       January 22, 2008

7.     Threshold(s) that is/are crossed or reached:

       M&G Investment Management Limited (wholly owned subsidiary of M&G Limited) has
       reached an 11% notifiable interest triggering this notification.

8.    Notified details:

      A: Voting rights attached to shares


Class/type of Situation previous to Resulting situation after the triggering           
shares        the Triggering        transaction                                        
              transaction                                                              
if possible  
using the     Number of  Number of  Number of  Number of voting    % of voting rights 
ISIN CODE     Shares     Voting     shares     rights                                 
                         Rights    
                                   Direct     Direct     Indirect Direct    Indirect

GB0006648157 59,097,037 59,097,037 59,254,839 59,254,839          11.03%           

Total (A+B)

Number of voting rights                % of voting rights
59,254,839                             11.03%



9.     Chain of controlled undertakings through which the voting rights and/or the
       financial instruments are effectively held, if applicable

       Prudential plc (parent Company)
       M&G Group Limited (wholly owned subsidiary of Prudential plc)
       M&G Limited (wholly owned subsidiary of M&G Group Limited)
       M&G Investment Management Limited (wholly owned subsidiary of M&G Limited)
       M&G Securities Limited (wholly owned subsidiary of M&G Limited)
       The Prudential Assurance Company Limited (wholly owned subsidiary of Prudential
       plc)

       Proxy Voting:

10.    Name of the proxy holder:

       n/a

11.    Number of voting rights proxy holder will cease to hold:

       n/a

12.   Date on which proxy holder will cease to hold voting rights:

      n/a


13.   Additional information:


14.   Contact Name

      Andrew Wood

      Oxford BioMedica

15.   Contact telephne number:

      01865 783 000






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