Notification of Shares

Oxford Biomedica PLC
18 January 2008


For immediate release                                            18 January 2008


                              OXFORD BIOMEDICA PLC


               TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached (ii):

Oxford BioMedica PLC



2. Reason for the notification (please state Yes/No): (    )

An acquisition or disposal of voting rights: ( Yes  )

An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached: (    )

An event changing the breakdown of voting rights: (    )

Other (please specify) :  (   )



3. Full name of person(s) subject to the notification obligation (iii):

    Prudential plc group of companies



4. Full name of shareholder(s) (if different from 3.) (iv):

Prudential plc (parent company)

M&G Group Limited (wholly owned subsidiary of Prudential plc)

M&G Limited (wholly owned subsidiary of M&G Group Limited)

M&G Investment Management Limited (wholly owned subsidiary of M&G Limited)

M&G Securities Limited (wholly owned subsidiary of M&G Limited)

The Prudential Assurance Company Limited (wholly owned subsidiary of Prudential
plc)



5. Date of the transaction (and date on which the threshold is crossed or
reached if different) (v):

     16 January 2008



6. Date on which issuer notified:

18 January 2008



7. Threshold(s) that is/are crossed or reached:

11%



8. Notified details:



A: Voting rights attached to shares


Class/type of shares if possible           Situation previous to the Triggering transaction (vi)
using the ISIN CODE
                                                    Number of shares        Number of voting Rights (viii)


GB0006648157                                              58,927,308                            58,927,308



Resulting situation after the triggering transaction (vii)
Class/type of shares if                Number of shares Number of voting rights (ix)  % of voting rights
possible using the ISIN CODE
                                                 Direct   Direct (x)   Indirect (xi)     Direct   Indirect


GB0006648157                                 59,097,037   59,097,037                     11.00%



B: Financial Instruments

Resulting situation after the triggering transaction (xii)
Type of         Expiration Date       Exercise/Conversion       Number of voting rights     % of voting rights
financial       (xiii)                Period/Date (xiv)         that may be acquired if the
instrument                                                      instrument is exercised/
                                                                converted.

N/A                               N/A                       N/A                         N/A                  N/A



Total (A+B)


       Number of voting rights            % of voting rights


              59,097,037                        11.00%



9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable (xv):

                   Registered Holder                                                Holding            %

Prudential plc     Total Notifiable Interest                                     59,097,037       11.00%
                   Norturst Nominee Ltd A/C MHF01                                   134,616
                   Nortrust Nominee Ltd A/C MKK01                                32,912,027
                   Nortrust Noms Ltd                                                124,000
                   PRUCLT HSBC GIS NOM (UK) PAC AC                               18,750,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                                7,176,026

M&G Group Limited                                                                59,097,037       11.00%
                   Norturst Nominee Ltd A/C MHF01                                   134,616
                   Nortrust Nominee Ltd A/C MKK01                                32,912,027
                   Nortrust Noms Ltd                                                124,000
                   PRUCLT HSBC GIS NOM (UK) PAC AC                               18,750,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                                7,176,026

M&G Investment Management Limited                                                58,962,421       10.97%
                   Nortrust Nominee Ltd A/C MKK01                                32,912,027
                   Nortrust Noms Ltd                                                124,000
                   PRUCLT HSBC GIS NOM (UK) PAC AC                               18,750,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                                7,176,026

M&G Limited                                                                      59,097,037       11.00%
                   Norturst Nominee Ltd A/C MHF01                                   134,616
                   Nortrust Nominee Ltd A/C MKK01                                32,912,027
                   Nortrust Noms Ltd                                                124,000
                   PRUCLT HSBC GIS NOM (UK) PAC AC                               18,750,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                                7,176,026

M&G Securities Limited                                                           33,046,643        6.15%
                   Norturst Nominee Ltd A/C MHF01                                   134,616
                   Nortrust Nominee Ltd A/C MKK01                                32,912,027

The Prudential Assurance Company Limited                                         25,926,394        4.82%
                   PRUCLT HSBC GIS NOM (UK) PAC AC                               18,750,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                                7,176,026




Proxy Voting:

10. Name of the proxy holder:

N/A



11. Number of voting rights proxy holder will cease to hold:

N/A



12. Date on which proxy holder will cease to hold voting rights:

N/A



13. Additional information:

N/A



14. Contact name:

Andrew Wood



15. Contact telephone number:

01865 783000



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