Chronotherapy Presentation

RNS Number : 7663V

Physiomics PLC

03 June 2008

 



Physiomics plc

The Magdalen Centre

The Oxford Science Park
Robert Robinson Avenue
Oxford

OX4 4GA
UK

Tel [phone]

Fax [phone]

03 June 2008            

Physiomics plc ('Physiomics' or 'the Company')

Physiomics to present on Chronotherapy at the Beyond Genome Conference

Physiomics plc (AIM: PYC), the Oxford, UK based systems biology company, is pleased to announce that it will be participating in the 2008 Beyond Genome conference, taking place in The Fairmont Hotel, San Francisco, California on 8-11 June 2008. Dr Christophe Chassagnole, Chief Operating Officer of Physiomics, was invited to give an oral presentation entitled “Optimal Cancer Chronotherapeutics Schedules Using a Systems Biology Approach” during  the “Applying Systems Biology-collaboration” session, scheduled at 11:15 am on 09 June. The Company’s chronotherapy research program is a part of the EU funded TEMPO (Temporal Genomics for Tailored Chronotherapeutics) project.

More information about the conference may be found at www.beyondgenome.com

For further information:

Physiomics plc                                                    [phone]

Dr Christophe Chassagnole, COO 

E-mail: [e-mail]

About TEMPO project (LSHG-CT-2006-037543)

In 2006 Physiomics has been selected to participate in the TEMPO Project as one of four Industry partners working closely with four distinguished European academic research groups. The project is coordinated by INSERM unit director Prof Francis Levi, at Paul Brousse hospital in Villejuif (France). TEMPO is a STREP project funded in part by the European Commission through its Life Sciences and Health Sixth Framework programme.

This three year programme is exploring the effect of circadian rhythms (the body's clock) on changes in cell proliferation and the effectiveness of cancer drugs and will use this knowledge to optimise treatment. The aim is to optimise treatment of individual patients taking into account the 24h rhythms generated by the patient's biological clock. Physiomics is using its cell simulation technologies to study the effect of cancer drugs on the cell cycle/circadian clock system behaviour, at the cellular level, the cell population level (virtual Fluorescence-Activated Cell-Sorting experiment) or tissue level (virtual tumour). Using pharmacokinetics simulation in connection with pharmacodynamics profile, Physiomics will help establish one or more physiological relevant drug regimes and delivery schedules. 

Physiomics will receive approximately £169,000 (€252,650) of matched funding over the three year period and if successful will share in 3 to 5 new therapeutic schedules according to the patient profiles for 2 main drug classes against cancer and more specifically colorectal cancer. TEMPO develops tools that will enable to select the best administration schedule for anti-cancer drugs, taking into account the genes expression profile of the patient. Under temporal control of the drug administration, the efficacy as well as the toxicity will be controlled in an optimised manner.

For further information, please visit www.chrono-tempo.org

About Physiomics plc

Physiomics plc (AIM:PYC) is a computational systems biology services company applying simulations of cell behaviour to drug development to reduce the high attrition rates of clinical trials. As 80-90 per cent of all clinical drug candidates fail to reach the market, estimates¹ show that an overall ten per cent improvement in success rates could reduce the cost of one drug's development by as much as $242 million, from the current estimate of around $800 million.

Physiomics develops computational systems biology models to predict and understand cancer drug efficacy from pre-clinical research to clinical development. Physiomics has created detailed mathematical models incorporating most important molecular events taking place during the human cell cycle and apoptosis processes. Physiomics developed SystemCell® technology, a multi-cellular environment software, which enables the simulation of population of 'virtual cells'.

Physiomics, based in Oxford, UK, was founded in 2001, and floated on AIM in 2004. For further information, please visit www.physiomics-plc.com

SystemCell® is a registered trademark of Physiomics plc

1Tufts Centre Impact Report 2002

 

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