Director Shareholding

Proteome Sciences PLC
26 November 2003

 

      Schedule 11 - Notification of interests of Directors and Connected Persons

                              25th November, 2003

1.     Name of company:

Proteome Sciences

2.     Name of director:

Dr. Sandra S. Steiner


        3.     Please state whether notification indicates that it is in respect
        of holding of the director named in 2 above or holding of that person's
        spouse or children under the age of 18 or in respect of a non-
        beneficial interest:

As in 2 above


        4.     Name of registered holder(s) and, if more than one holder, the
        number of shares held by each of them (if notified):

As in 2 above


        5.     Please state whether notification relates to a person(s)
        connected with the director named in 2 above and identify the connected
        person(s):

N/A


        6.     Please state the nature of the transaction. For PEP transactions
        please indicate whether general/single co PEP and if discretionary/non
        discretionary:

Grant of Options

7.     Number of shares/amount of stock acquired:

N/A


8.     Percentage of issued class:

N/A

9.     Number of shares/amount of stock disposed:

N/A


10.     Percentage of issued class:




11.     Class of security:




12.     Price per share:



13.     Date of transaction:

14.     Date company informed:

15.      Total holding following this notification:



16.     Total percentage holding of issued class following this notification:


        If a director has been granted options by the company, please complete
        the following fields:




17.     Date of grant:



        25th November, 2003

18.     Period during which or date on which exercisable:



        25.11.2006 to 25.11.2010

19.     Total amount paid (if any) for grant of the option:

N/A



20.     Description of shares or debentures involved: class, number:

100,000 ordinary shares of 1p


        21.     Exercise price (if fixed at time of grant) or indication that
        price is to be fixed at time of exercise:

184.5p

        22.     Total number of shares or debentures over which options held
        following this notification:

450,000

23.     Contact name for queries:

James Malthouse - finance director

24.     Contact telephone number:

01932 865065

25.     Name of company official responsible for making notification:


James Malthouse - finance director - 26 November 2003




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