Holding(s) in Company

Provexis PLC
17 April 2007

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1.  Identity of the issuer or the underlying issuer of existing shares to
    which voting rights are attached
    PROVEXIS PLC

2.  Reason for the notification (please tick the appropriate box or boxes)

    An acquisition or disposal of voting rights                       (X)

    An acquisition or disposal of financial instruments which may     ( )
    result in the acquisition of shares already issued to which
    voting rights are attached

    An event changing the breakdown of voting rights                  ( )

    Other (specify):                                                  ( )

3.  Full name of person(s) subject to the notification obligation:
    City Equities Ltd

4.  Full name of shareholder(s) (if different from 3.)


5.  Date of the transaction (and date on which the threshold is crossed
    or reached if different):
    12 April 2007

6.  Date on which issuer notified:
    13 April 2007

7.  Threshold(s) that is/are crossed or reached:
    3%

8.  Notified details:

A. Voting rights attached to shares

Class/type of shares (if possible using the           Ordinary (GB00B0923P27)
ISIN code)

Situation previous to      Resulting situation after the triggering transaction
the triggering
transaction
Number of   Number of      Number of   Number of voting     % of voting rights
Shares      Voting         shares      rights
            Rights
                           Direct      Direct   Indirect    Direct    Indirect
20,093,334  20,093,334

B. Financial Instruments

Resulting situation after the triggering transaction
Type of       Expiration   Exercise/          Number of voting  % of voting
financial     date         Conversion Period/ rights that may   rights
instrument                 Date               be acquired if
                                              the instrument is
                                              exercised/
                                              converted

Total (A+B)
Number of voting rights              % of voting rights


9.  Chain of controlled undertakings through which the voting rights and/
    or the financial instruments are effectively held, if applicable:

Proxy Voting:
10.  Name of the proxy holder:

11.  Number of voting rights proxy
     holder will cease to hold:

12.  Date on which proxy holder
     will cease to hold voting
     rights:

13.  Additional information:       Sold to certain private customers, with
                                   City Equities Limited acting as
                                   Principal

14:  Contact name:                 Andrew Thacker

15.  Contact telephone number:     020 7489 5536




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