Redx to Present Poster on RXC007 at ICLAF

RNS Number : 1427B

Redx Pharma plc

29 September 2022

 

REDX PHARMA PLC

("Redx" or "the Company")

Redx to Present Poster on Encouraging Preclinical Fibrosis Data for RXC007 at the 21st International Colloquium on Lung and Airway Fibrosis

Alderley Park, 29 September 2022 Redx (AIM: REDX) , the clinical-stage biotechnology company focused on discovering and developing novel, small molecule, highly targeted therapeutics for the treatment of cancer and fibrotic disease, today announces that it will present a poster on RXC007 at the forthcoming 21st International Colloquium on Lung and Airway Fibrosis (1-5 October 2022, Reykjavik, Iceland/virtual).

The poster will present RXC007 preclinical efficacy data across fibrosis models, and Phase 1 data for single and multiple (up to 14 days) ascending dose studies in healthy male volunteers. RXC007, Redx's lead fibrosis asset, is a highly selective ROCK 2 inhibitor, which is expected to enter Phase 2a clinical studies for lead indication idiopathic pulmonary fibrosis (IPF) in 2022, following encouraging Phase 1 safety and pharmacokinetic data.

Title:	RXC007, a potent, highly selective ROCK2 inhibitor, demonstrates preclinical efficacy across fibrosis models and good Phase 1 safety profile, supporting development in IPF and ILD.
Abstract number:	66
Abstract code:	PDD-08
Day/Date:	Sunday, 2 October 2022
Time:	15:00-16:30
Session name and category:	Posters - Drug Development

A copy of the poster will be made available on the Company's website following the presentation at:  https://www.redxpharma.com/scientific-publications/  

For further information, please contact:
Redx Pharma Plc  UK Headquarters Caitlin Pearson, Head of Communications [e-mail]   Lisa Anson, Chief Executive Officer	T: [phone]
US Office Peter Collum, Chief Financial Officer
SPARK Advisory Partners (Nominated Adviser)	T: [phone]
Matt Davis/ Adam Dawes
WG Partners LLP (Joint Broker)	T: [phone]
Claes Spång/ Satheesh Nadarajah/ David Wilson
Panmure Gordon (UK) Limited (Joint Broker)	T: [phone]
Rupert Dearden/ Freddy Crossley/ Emma Earl
FTI Consulting	T: [phone]
Simon Conway/ Ciara Martin

About Redx Pharma Plc

Redx Pharma (AIM: REDX) is a clinical-stage biotechnology company focused on the discovery and development of novel, small molecule, highly targeted therapeutics for the treatment of cancer and fibrotic diseases, aiming initially to progress them to clinical proof of concept before evaluating options for further development and potential value creation. Redx's lead oncology product candidate, the Porcupine inhibitor RXC004, commenced a Phase 2 programme in November 2021. The Company's selective ROCK2 inhibitor product candidate, RXC007, is in development for idiopathic pulmonary fibrosis and commenced a Phase 1 clinical trial in June 2021. Encouraging safety and pharmacokinetic data has been reported, and a Phase 2 clinical program is confirmed to start in 2022. Redx's third drug candidate, RXC008, a GI-targeted ROCK inhibitor for the treatment of fibrostenotic Crohn's disease, is currently in pre-IND stage, with Phase 1 clinical studies expected to commence in 2023.

The Company has a strong track record of discovering new drug candidates through its core strengths in medicinal chemistry and translational science, enabling the Company to discover and develop differentiated therapeutics against biologically or clinically validated targets. The Company's accomplishments are evidenced not only by its two wholly-owned clinical-stage product candidates and rapidly expanding pipeline, but also by its strategic transactions, including the sale of pirtobrutinib (RXC005, LOXO-305), a BTK inhibitor now in Phase 3 clinical development by Eli Lilly following its acquisition of Loxo Oncology, and RXC006, a Porcupine inhibitor targeting fibrotic diseases including idiopathic pulmonary fibrosis (IPF), which AstraZeneca is progressing in a Phase 1 clinical study. In addition, Redx has forged collaborations with Jazz Pharmaceuticals, which includes JZP815, a preclinical pan-RAF inhibitor, which has received IND clearance from the US FDA, and an early stage oncology research collaboration.  

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