Director/PDMR Shareholding

ReNeuron Group plc
16 September 2005



NOTIFICATION OF TRANSACTIONS OF DIRECTORS/PERSONS DISCHARGING
MANAGERIAL RESPONSIBILITY AND CONNECTED PERSONS


This form is intended for use by an issuer to make a RIS notification required
by DR 3.1.4R(1).



(1)          An issuer making a notification in respect of a transaction
relating to the shares or debentures of the issuer should complete boxes 1 to
16, 23 and 24.



(2)          An issuer making a notification in respect of a derivative relating
to the shares of the issuer should complete boxes 1 to 4, 6, 8,13, 14, 16, 23
and 24.



(3)          An issuer making a notification in respect of options granted to a
director/person discharging

managerial responsibilities should complete boxes 1 to 3 and 17 to 24.



(4)               An issuer making a notification in respect of a financial
instrument relating to the shares of the issuer (other than a debenture) should
complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.



Please complete all relevant boxes in block capital letters.


1.      Name of the issuer                            2.    State whether the notification relates to (i)
                                                            a transaction notified in accordance with DR
                                                            3.1.4R(1)(a); or



        RENEURON GROUP PLC                                  (ii) DR3.1.4(R)(1)(b) a disclosure made in
                                                            accordance with section 324 (as extended by
                                                            section 328) of the Companies Act 1985;  or



                                                            (iii) both (i) and (ii)



                                                            (ii)






3.      Name of person discharging managerial         4.    State whether notification relates to a person
        responsibilities/director                           connected with a person discharging managerial
                                                            responsibilities/director named in 3 and
        PAUL HARPER                                         identify the connected person
        TREVOR JONES




5.      Indicate whether the notification is in       6.    Description of shares (including class),
        respect of a holding of the person referred         debentures or derivatives or financial
        to in 3 or 4 above or in respect of a               instruments relating to shares
        non-beneficial interest3




7.      Name of registered shareholders(s) and, if    8.    State the nature of the transaction
        more than one, the number of shares held by
        each of them



9.      Number of shares, debentures or financial     10.   Percentage of issued class acquired (treasury
        instruments relating to shares acquired             shares of that class should not be taken into
                                                            account when calculating percentage)





11.     Number of shares, debentures or financial     12.   Percentage of issued class disposed (treasury
        instruments relating to shares disposed             shares of that class should not be taken into
                                                            account when calculating percentage)



13.     Price per share or value of transaction       14.   Date and place of transaction



15.     Total holding following notification and      16.   Date issuer informed of transaction
        total percentage holding following
        notification (any treasury shares should not
        be taken into account when calculating
        percentage)




If a person discharging managerial responsibilities has been granted options by
the issuer



complete the following boxes




17.    Date of grant                               18.  Period during which or date on which it can be
                                                        exercised

                                                        DURING THE 10 YEAR PERIOD FOLLOWING GRANT,
                                                        SUBJECT TO VESTING AND PERFORMANCE CONDIDTIONS
       6 SEPTEMBER 2005 (FOR EACH)



19.    Total amount paid (if any) for grant of the 20.  Description of shares or debentures involved
       option                                           (class and number)

                                                        PAUL HARPER 50,000 ORDINARY SHARES
                                                        TREVOR JONES 50,000 ORDINARY SHARES
       NIL                                              MICHAEL HUNT 1,000,000 ORDINARY SHARES

21.    Exercise price (if fixed at time of grant)  22.  Total number of shares or debentures over
       or indication that price is to be fixed at       which options held following notification
       the time of exercise                             PAUL HARPER: 50,000 OPTIONS
                                                        TREVOR JONES: 150,000 OPTIONS
       £0.25 PER SHARE                                  MICHAEL HUNT 1,929,500 OPTIONS AND WARRANTS








23.    Any additional information                  24.  Name of contact and telephone number for
                                                        queries

                                                        TIM MICKLEY, COLLINS STEWART 020 7523 8000
       NON EXECUTIVE FLOTATION OPTIONS GRANTED
       UNDER THE COMPANY'S NON EXECUTIVE SHARE          MICHAEL HUNT RENEURON 01483 302 560
       OPTION SCHEME





  Name and signature of duly authorised officer of issuer responsible for making notification



  MICHAEL HUNT CHIEF EXECUTIVE OFFICER-______________________________________



  Date of notification           16/9/05










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