Half Yearly Report

RNS Number : 1091D
ReNeuron Group plc
26 November 2009
 



GuildfordUK: 26 November 2009


ReNeuron Group plc 

 Interim Results for the six months ended 30 September 2009 



Operational Highlights


  • ReN001 stem cell therapy for stroke:
    • Favourable ethical opinion, subject to conditions, given by UK ethics body for Phase I clinical trial, following earlier UK regulatory approval
    • Supplemental data package subsequently generated to meet remaining ethical approval condition 
    • Five peer-reviewed papers published in the period regarding safety, efficacy, mechanism of action and manufacture of lead CTX stem cell line used in ReN001 programme
  • Positive pre-clinical efficacy data presented with ReN009 stem cell therapy for peripheral arterial disease - initial clinical trial targeted to commence in 2011 using CTX stem cell line
  • Long shelf-life, frozen formulation of CTX cell product developed, for subsequent clinical application in ReN001 and ReN009 programmes
  • Three further peer-reviewed papers published in the period regarding positive pre-clinical data with ReN003 cell line for retinal diseases and research with ReNcell® product for non-therapeutic applications
  • ReNeuron's Guildford facility granted full therapeutic application licence by UK Human Tissue Authority, following audit


Financial Highlights


  • Share placing to raise £3.0 million, before expenses, completed in the period, together with capitalisation of outstanding £2.5 million convertible loan notes and accrued interest 
  • Further £5.0 million equity finance facility secured from the Company's joint broker, Matrix Corporate Capital LLP, post-period end, meeting funding requirements through to mid-2011, assuming facility is fully utilised
  • Loss for the period reduced by 39% to £1.9 million (2008: £3.1 million); net cash outflow from operating activities reduced by 50% to £1.5 million (2008: £3.0 million); cash and cash equivalents at 30 September 2009 of £2.1 million (2008: £0.8 million).


Commenting on the results, Professor Trevor Jones, Chairman, said:


"During the six months to 30 September 2009, and subsequently, we have made significant progress across all areas of our operations. After a lengthy and exhaustive review process, our pioneering ReN001 therapy for stroke has received both UK regulatory and conditional ethical approvals for a first-in-man clinical study and we remain confident of meeting the remaining requirements to allow initiation of this clinical trial early in 2010.  


"Our ReN009 therapy for peripheral arterial disease in diabetics is showing great promise pre-clinically, with an initial clinical trial targeted for 2011. Furthermore, we have developed a commercially attractive, second-generation formulation of our lead CTX cell line, our core therapeutic asset. We have a much reduced cost base reflected in the interim results for the period and we have also greatly enhanced the Group's financial position by way of a £3 million equity placing during the period and a further £5 million equity draw-down facility secured subsequently. We look forward to a period of further substantial progress over the coming year."



Enquiries:


Michael Hunt, Chief Executive Officer

Dr John Sinden, Chief Scientific Officer

ReNeuron Group plc

+44 (0) 1483 302560



Jonathan BirtSusan Quigley

Financial Dynamics

+44 (0) 20 7831 3113



Simon Leathers, Emma Earl 

Daniel Stewart & Company plc 


+44 (0) 20 7776 6550



Alastair Stratton, Tim Graham 

Matrix Corporate Capital LLP 

+44 (0) 20 3206 7000



Chairman's and Chief Executive Officer's Joint Statement


Review of Operations


During the six months ended 30 September 2009, we received a final and favourable ethical opinion, subject to conditions, from the UK Gene Therapy Advisory Committee (GTAC) in respect of the proposed first-in-man clinical trial with ReN001, our stem cell therapy for stroke. GTAC acts as the national research ethics committee for gene therapy and stem cell therapy clinical trials in the UK. This final ethical opinion followed regulatory approval for the clinical trial granted by the UK Medicines and Healthcare Products Regulatory Agency (MHRA) earlier in the year. This ground-breaking Phase I trial with ReN001 will take place in Scotland at Glasgow's Southern General Hospital, in patients who have been left disabled by a stroke.


In subsequent interactions with both GTAC and the MHRA, we have agreed appropriate amendments to the proposed clinical trial protocol. We are also finalising the supplemental pre-clinical data package requested by GTAC as a condition of their favourable ethical opinion, which we will submit for their review shortly. Assuming a swift and successful outcome, we expect the ReN001 Phase I clinical trial to commence in the first quarter of 2010.


During the period, a total of five peer-reviewed papers were published in separate scientific journals regarding the efficacy, safety, mechanism of action and manufacture of our lead CTX stem cell line and its application as our ReN001 therapeutic candidate for stroke. These papers describe work performed both by ReNeuron's own researchers and research undertaken in collaboration with UK and US academic institutions. We will continue to foster our relationships with academia and publish key findings with our various technologies and stem cell lines, in order to further exemplify the very significant therapeutic and commercial potential we believe they hold.


We made very encouraging progress with our ReN009 stem cell therapy for peripheral arterial disease (PAD) during the period. PAD is a chronic and debilitating disease that progressively restricts blood flow in the limbs, causing cramping, chronic pain and in extreme cases, loss of limb. The disease is commonly associated with other conditions such as diabetes, obesity and stroke. At least 1 in 20 people over the age of 55 have some degree of PAD and it becomes more common with increasing age. Pre-clinical efficacy testing of ReN009 is being conducted in collaboration with Professor Paolo Madeddu, Chair of Experimental Cardiovascular Medicine and colleagues at the Bristol Heart Institute, University of Bristol. Following the presentation of initial positive pre-clinical efficacy data with ReN009 in April of this year, the Bristol team recently presented further positive pre-clinical efficacy data in an award-winning poster at the American Heart Association Scientific Sessions in OrlandoFlorida.


The ReN009 programme will utilise our well-characterised, lead CTX stem cell line as an allogeneic (non-patient specific) stem cell treatment candidate for late-stage PAD, or critical limb ischaemia, in diabetic patients for whom PAD is a side-effect of their diabetes. Further pre-clinical studies are currently in progress with ReN009 focusing on diabetic models, the results of which will be reported in early 2010. In the meantime, we have recently taken a scientific advice meeting with the MHRA, and we have scheduled a further meeting with GTAC shortly, in order to discuss and agree certain aspects of the late pre-clinical development plan for the ReN009 therapy. Equivalent meetings are also planned with regulatory authorities in other territories, including the US, ahead of initial clinical trials expected to commence in 2011.  

  

During the period, we successfully prototyped a second-generation, long shelf-life, frozen formulation of the CTX cells for subsequent pre-clinical and clinical use in the Company's ReN001 and ReN009 programmes. This new freeze-thaw formulation makes possible the scale-up and production of CTX cells for wide-scale use across the globe, both clinically and commercially. This scale-up capability should therefore provide the Company with a key advantage when seeking commercial development partners for its therapies. The technology is currently being transferred to our contract manufacturing partner, Angel Biotechnology in Scotland.


Two further peer-reviewed papers were published in the period regarding positive pre-clinical data generated with our ReN003 cell line for retinal diseases, by our collaborators at the Schepens Eye Research Institute at Harvard Medical School. A significant paper was also published by US researchers in the period, describing how ReNeuron's ReNcell®VM cell line was successfully re-programmed to generate stable human induced pluripotent stem cells (iPS cells), similar to human embryonic stem cells with the ability to differentiate into any type of cell in the body. We are encouraged by the increasing interest in our range of ReNcell® products for non-therapeutic applications by both academic and commercial researchers, since licensing them to Millipore Corporation for world-wide marketing and distribution.


We were also pleased to have met all the necessary conditions pertaining to the grant of a therapeutic application licence to ReNeuron by the UK Human Tissue Authority during the period, following their earlier audit of our Guildford research facility.


During the period, we announced the appointment of Daniel Stewart & Company plc as Nominated Adviser and joint broker, and Matrix Corporate Capital LLP ("Matrix") as joint broker, to the Company.  


Summary of Results


In the six months to 30 September 2009, revenues were £14,000 (2008: £6,000), representing royalty income from the Group's non-therapeutic licensing activities.


Net operating expenses were £2.0 million in the period (2008: £3.1 million). Research and development expenditure decreased in the period to £1.1 million (2008: £1.9 million), due principally to the continuing effects of the cost reduction programme instigated in mid-2008, together with a further reduction in outsourced cell banking and testing costs in the ReN001 stroke programme. General and administrative costs also decreased in the period to £0.9 million (2008: £1.2 million), due principally to cost savings associated with the closure of the Company's US facility as part of the cost reduction programme.


Interest received decreased in the period to £7,000 (2008: £45,000) as a result of lower interest rates available on the Company's cash deposits over the period. Interest costs also decreased slightly to £10,000 in the period (2008: £14,000), relating to interest accrued on the outstanding convertible loan notes referred to below that were fully capitalised during the period.


The Group has accrued a research and development tax credit of £154,000 during the period. No equivalent accrual was made in the prior period due to uncertainty over the Group's ability to claim such credits at that time.


As a result of the above income statement movements, together with the effects of currency translation losses of £13,000 during the period (2008: £7,000 gain), the total comprehensive loss for the period decreased to £1.9 million (2008: £3.1 million).


Net cash outflow from operating activities decreased in the period to £1.5 million (2008: £3.0 million), due largely to the decrease in operating expenses in the period. During the period, the Group completed a further equity funding of £3.0 million before expenses, by way of a placing of new ordinary shares. In connection with this placing, a total of £2.5 million of outstanding convertible loan notes, together with accrued interest thereon, were capitalised.


As a result of the above cash flow movements in the period, the Group had cash and cash equivalents totalling £2.1 million as at 30 September 2009 (2008: £0.8 million). 


In November 2009, the Group secured a further £5 million equity funding facility from Matrix, available for draw-down over a two year period. Draw-down amounts are calculated according to a formula based on the daily trading volume of the Company's ordinary shares, and their volume-weighted average price, over relevant trading periods. An over-allotment option also exists in the facility to enable larger draw-downs to be made should market conditions allow at the time.  In the absence of any funding from other sources and allowing for the Group's existing cash resources, the Matrix equity facility will provide sufficient working capital to fund the Group's current operations through to mid-2011, if fully utilised over that period.  


The directors expect the Group's current financial resources (excluding future funding available under the Matrix equity facility) to last into the second quarter of 2010. The directors are confident of raising further funds sufficient to meet the Group's ongoing requirements thereafter, both by draw-downs under the Matrix equity facility and by the issue of further equity or other financial instruments. The directors are also actively pursuing a number of non-dilutive governmental, regional and charitable translational funding sources. Based on the above, the going concern basis has been adopted in the preparation of these interim financial statements.


Outlook


During the period under review, and subsequently, we have made significant progress across all areas of our operations. After a lengthy and exhaustive review process, our pioneering ReN001 therapy for stroke has received both UK regulatory and conditional ethical approvals for a first-in-man clinical study and we remain confident of meeting the remaining requirements to allow initiation of this clinical trial early in 2010.  


Our ReN009 therapy for peripheral arterial disease in diabetics is showing great promise pre-clinically, with an initial clinical trial targeted for 2011. Further, we have developed a commercially attractive, second-generation formulation of our lead CTX cell line, our core therapeutic asset. We have a much reduced cost base reflected in the interim results for the period and we have also greatly enhanced the Group's financial position by way of a £3 million equity placing during the period and a further £5 million equity draw-down facility secured subsequently. We look forward to a period of further substantial progress over the coming year.



Professor Trevor Jones

Michael Hunt

Chairman

Chief Executive Officer


26 November 2009




Unaudited Consolidated Statement of Comprehensive Income

for the six months ended 30 September 2009





Six months ended

Six months ended

Year ended



 30 September

 30 September

 31 March



2009

 2008

2009


Note

£'000

£'000

£'000

Revenue


14 

93 

Research and development costs


(1,138)

(1,939)

(3,177)

General and administrative costs


(888)

(1,192)

(1,594)

Operating loss


(2,012)

(3,125)

(4,678)

Finance income


45 

63 

Finance costs


(10)

(14)

(62)

Loss before income taxes


(2,015)

(3,094)

(4,677)

Tax credit on loss on ordinary activities


154 

-

1,000 

Loss for the period


(1,861)

(3,094)

(3,677)

Other comprehensive income





Currency translation differences


(13)

10 

Total comprehensive loss for the period


(1,874)

(3,087)

(3,667)

Loss attributable to:





  - Equity owners of the company


(1,861)

(3,094)

(3,677)

Total comprehensive loss attributable to:





  - Equity owners of the company


(1,874)

(3,087)

(3,667)






Basic and diluted loss per share

3

(0.6p)

(2.0p)

(2.4p)



All revenues and expenses above were generated from continuing operations.



Unaudited Consolidated Statement of Financial Position

as at 30 September 2009





30 September

30 September

31 March



2009

2008

2009

 

Note

£'000

£'000

£'000

Assets





Non-current assets





Property, plant and equipment


755 

913 

834 

Intangible assets


3,419 

3,419 

3,419 

Other non-current assets


135 

135 

135 

 


4,309 

4,467 

4,388 

Current assets





Trade and other receivables


821 

432 

1,024 

Cash and cash equivalents


2,146 

840 

943 

 


2,967 

1,272 

1,967 

Total assets


7,276 

5,739 

6,355 






Equity





Equity attributable to owners of the company





Share capital


3,396 

1,542 

1,542 

Share premium 


17,792 

14,358 

14,358 

Equity element of convertible loan note


-

184 

-

Capital redemption reserve


8,964 

8,964 

8,964 

Merger reserve


2,223 

2,223 

2,223 

Warrant reserve


113 

113 

583 

Share-based credit reserve


682 

432 

504 

Retained deficit


(26,563)

(23,676)

(24,689)

Total equity


6,607 

4,140 

3,485 

Liabilities





Non-current liabilities





Convertible loan

7

-

828 

2,088 

 


-

828 

2,088 

Current Liabilities





Trade and other payables


634 

722 

740 

Financial liabilities: finance leases


35 

49 

42 

 


669 

771 

782 

Total liabilities


669 

1,599 

2,870 

Total equity and liabilities


7,276 

5,739 

6,355 



Unaudited Consolidated Statement of Changes in Equity

for the six months ended 30 September 2009









Share-





Share

Capital



based




Share

premium

redemption

Merger

Warrant

credit

Retained

Total


capital

account

reserve

reserve

reserve

reserve

deficit

Equity


£'000

£'000

£'000

£'000

£'000

£'000

£'000

£'000

As at 1 April 2008

1,542 

14,358 

8,964 

2,223 

113 

329 

(20,589)

6,940 










Equity element of convertible loan

-

-

-

-

184 

-

-

184 










Share-based credit

-

-

-

-

-

103 

-

103 










Loss for the period

-

-

-

-

-

-

(3,094)

(3,094)










Other comprehensive income:









Currency translation differences

-

-

-

-

-

-










As at 30 September 2008

1,542 

14,358 

8,964 

2,223 

297 

432 

(23,676)

4,140 










Equity element of convertible loan

-

-

-

-

286 

-

-

286 










Share-based credit

-

-

-

-

-

72 

-

72 










Loss on foreign exchange translation

-

-

-

-

-

-

(433)

(433)










Loss for the period

-

-

-

-

-

-

(590)

(590)










Other comprehensive income:









Currency translation differences

-

-

-

-

-

-

10 

10 


 

 

 

 

 

 

 

 

As at 31 March 2009

1,542 

14,358 

8,964 

2,223 

583 

504 

(24,689)

3,485 










Issue of new ordinary shares

1,697 

3,396 

-

-

-

-

-

5,093 










Costs of share issue

-

(275)

-

-

-

-

-

(275)










Conversion of convertible loan to equity

157 

313 

-

-

(470)

-

-

-










Share-based credit

-

-

-

-

-

178 

-

178 










Loss for the period

-

-

-

-

-

-

(1,861)

(1,861)










Other comprehensive income:









Currency translation differences

-

-

-

-

-

-

(13)

(13)










As at 30 September 2009

3,396 

17,792 

8,964 

2,223 

113 

682 

(26,563)

6,607 



Unaudited Consolidated Statement of Cash Flows

for the six months ended 30 September 2009





Six months ended

Six months ended

Year ended



30 September

30 September

 31 March



2009

2008

2009

 

Note

£'000

£'000

£'000

Cash consumed by operations

4

(1,518)

(2,989)

(4,697)

Interest paid


(2)

(14)

(4)

Income tax credit received


-

-

300 

Cash outflow from operating activities


(1,520)

(3,003)

(4,401)






Cash flows from investing activities





Capital expenditure


-

(29)

(28)

Proceeds from sale of fixed assets


-

41 

41 

Interest received


45 

63 

Net cash generated in investing activities


57 

76 






Cash flows from financing activities





Finance lease principal payments


(7)

(5)

(12)

Convertible loan note proceeds


-

1,000 

2,500 

Proceeds from issuance of ordinary shares

7

2,998 

-

-

Costs of share issue


(275)

-

-

Net cash generated by financing activities


2,716 

995 

2,488 






Net increase/(decrease) in cash and cash equivalents

5

1,203 

(1,951)

(1,837)

Loss on foreign exchange translation


-

-

(11)

Cash and cash equivalents at the start of period


943 

2,791 

2,791 

Cash and cash equivalents at the end of period

6

2,146 

840 

943 



Notes to the interim financial statements

for the six months ended 30 September 2009


1.    Accounting policies and basis of preparation


1.1    Basis of preparation


The Group's unaudited interim results for the half year ended 30 September 2009 have been prepared in accordance with International Financial Reporting standards (IFRS). The comparative figures for the full year ended 31 March 2009 are an abridged version of the Group's audited financial statements and, together with other financial information contained in these interim results, do not constitute statutory financial statements of the Group within the meaning of section 434 of the Companies Act 2006.


This condensed consolidated interim financial information does not constitute statutory accounts within the meaning of Section 434 of the Companies Act 2006. Statutory financial statements for the year ended 31 March 2009 have been filed with the Registrar of Companies for England and Wales and have been reported on by the Group's auditors. The report of the auditors was not qualified, did not contain any statement under section 498 of the Companies Act 2006, but did contain an emphasis of matter paragraph relating to going concern.

 

1.2    Accounting policies


The accounting policies used in the preparation of these unaudited interim financial statements are consistent with those used in the preparation of the audited financial statements for the year ending 31 March 2009, except as described below.


A number of new and amended standards become effective for periods beginning on or after 1 January 2009. The principal changes that are relevant to the Group are:


IFRS 8 - Operating Statements

IFRS 8 is a disclosure standard only; there has been no effect on the reported results or previous financial position of the Group. The Group's reportable segments as reported under IAS 14 have remained unchanged following the adoption of this standard.


IAS 1 (revised 2007) - Presentation of Financial Statements

The revised standard has introduced a number of terminology changes (including revised titles for the condensed financial statements) and has resulted in a number of changes in presentation and disclosure. There has been no effect on the reported results or previous financial position of the Group.


1.3    Going concern


The Group is developing its technologies for the marketplace and as such absorbs cash until sufficient funds from either licensing or products sold are generated. The directors estimate that the cash held by the Group (excluding future funding available under the Matrix equity facility described in Note 8 below), will not be sufficient to support the current level of activities for the next twelve months. 


However, in the absence of any funding from other sources but assuming full utilisation of the £5 million Matrix equity facility, the directors believe there will be sufficient working capital to fund the Group's current operations through to mid-2011. Based on this, the going concern basis has been adopted in the preparation of these interim financial statements. Furthermore, the directors are confident of raising additional funds by the issue of further equity or other financial instruments. The directors are also actively pursuing a number of non-dilutive governmental, regional and charitable translational funding sources. 


If the directors considered that the going concern basis was no longer appropriate, adjustments would have to be made to revise the balance sheet value of assets to their realisable amounts and to provide for further liabilities that may arise.


2.    Segment information


Following the adoption of IFRS8 Segment Reporting, the Group has identified the Board of Directors as the Chief Operating Decision Maker (CODM). The CODM manages the business as one segment, the development of cell-based therapies. Since this is the only reporting segment, no further information is included. The information used internally by the CODM is the same as that disclosed in the interim financial statements.


3.    Basic and diluted loss per share


The basic and diluted loss per share is calculated by dividing the loss for the financial period of £1,874,000 (September 2008: £3,087,000, March 2009: £3,667,000) by 303,885,153 shares (September 2008: 154,167,534 shares, March 2009: 154,167,354 shares), being the weighted average number of ordinary 1p shares in issue during the period. Potential ordinary shares are not treated as dilutive as the entity is loss making. 


4.    Cash consumed by operations



Six months ended

Six months ended

Year ended


30 September

30 September

 31 March


2009

2008

2009

 

£'000

£'000

£'000

Loss before income tax

(2,015)

(3,094)

(4,677)

Adjustment for:




  Interest received

(7)

(45)

(63)

  Interest payable

10 

14 

62 

  Currency translation differences

(13)

10 

  Depreciation of tangible fixed assets

79 

117 

197 

  Provisions

-

-

25 

  Share-based payment charge

178 

103 

175 

  (Profit) on sale of fixed assets

-

(39)

(39)





Changes in working capital




  Receivables

356 

(21)

86 

  Payables

(106)

(31)

(473)

Cash consumed by operations

(1,518)

(2,989)

(4,697)


5.    Reconciliation of net cash flow to movement in net debt







Six months ended

Six months ended

Year ended


30 September

30 September

 31 March


2009

2008

2009


£'000

£'000

£'000

 

 

 

 

Net (debt)/funds at start of period

(1,187)

2,737 

2,737 





Increase/(decrease) in cash in the period

1,203 

(1,951)

(1,848)

Non cash movement

-

172 

412 

Cash inflow from decrease/(increase) in debt

2,095 

(995)

(2,488)

Net funds/(debt) at end of period

2,111 

(37)

(1,187)


6.    Analysis of net funds







Six months ended

Six months ended

Year ended


30 September

30 September

 31 March


2009

2008

2009


£'000

£'000

£'000

 

 

 

 

Cash at bank and in hand

2,146 

840 

943 

Finance leases

(35)

(49)

(42)

Convertible loan

-

(828)

(2,088)

 

2,111 

(37)

(1,187)


7.    Share Placing and Conversion of Convertible Loan


In June 2008, the Group secured £2.5m of financing from its principal existing investors by way of a subscription for a series of new secured loan notes issued by the Group. As at 31 March 2009, this facility had been drawn down in full. On 12 March 2009, the Group announced its intention to raise up to £3 million, before expenses, via a placing of up to 100,000,000 new ordinary shares of 1 pence each credited as fully paid up at a price of 3 pence per ordinary share. The placing comprised four closings to enable certain placees to take advantage of UK Enterprise Investment Scheme tax treatment. On 18 May 2009, the Group announced the completion of the fourth and final closing of the placing, bringing the aggregate gross proceeds of the placing to the full £3 million. In connection with the placing, a further 85,526,648 ordinary shares were allotted and issued on capitalisation of the full £2.5 million of outstanding loan notes (together with accrued interest) at a price of 3 pence per ordinary share. Following the fourth and final closing of the Placing and the issue of ordinary shares on capitalisation of all outstanding loan notes (together with accrued interest), the issued share capital of ReNeuron Group plc comprised 339,627,516 ordinary shares.


8.    Post-balance sheet event


In November 2009, the Company secured a two-year, gross £5 million equity funding facility from Matrix, the Company's joint broker. The Flexible Use Small Capital Increase Agreement will enable the Group to service its ongoing working capital requirements by drawing on this facility, as required, over the next two years. The Company will control the timing and amount of any draw-down and is under no obligation to make any such draw-down. If a draw-down is made, the Company will issue new Ordinary Shares to Matrix at a price per share calculated according to a formula based on the daily trading volume of the Company's Ordinary Shares, and their volume-weighted average price, over relevant trading periods. The facility also incorporates an over-allotment option to enable larger draw-downs to be made, should market conditions allow at the time.



Notes to Editors


ReNeuron is a leading, UK-based stem cell business. Its primary objective is the development of stem cell therapies targeting areas of significant unmet or poorly met medical need.  


ReNeuron has received regulatory and conditional ethical approvals to commence a Phase I clinical trial in the UK with its lead ReN001 stem cell therapy for disabled stroke patients. The Company is developing stem cell therapies for a number of other conditions, including peripheral arterial disease and diseases of the retina.


ReNeuron has also developed a range of stem cell lines for non-therapeutic applications - its ReNcell® products for use in academic and commercial research. The Company's ReNcell®CX and ReNcell®VM neural cell lines are marketed worldwide under license by USA-based Millipore Corporation.


ReNeuron's shares are traded on the London AIM market under the symbol RENE.L. Further information on ReNeuron and its products can be found at www.reneuron.com.


This announcement contains forward-looking statements with respect to the financial condition, results of operations and business achievements/performance of ReNeuron and certain of the plans and objectives of management of ReNeuron with respect thereto. These statements may generally, but not always, be identified by the use of words such as "should", "expects", "estimates", "believes" or similar expressions. This announcement also contains forward-looking statements attributed to certain third parties relating to their estimates regarding the growth of markets and demand for products. By their nature, forward-looking statements involve risk and uncertainty because they reflect ReNeuron's current expectations and assumptions as to future events and circumstances that may not prove accurate. A number of factors could cause ReNeuron's actual financial condition, results of operations and business achievements/performance to differ materially from the estimates made or implied in such forward-looking statements and, accordingly, reliance should not be placed on such statements.


The terms 'ReNeuron', 'the Company' or 'the Group' used in this statement refer to ReNeuron Group plc and/or its subsidiary undertakings, depending on the context.






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