NOTIFICATION OF MAJOR INTERESTS IN SHARES
1. Name of company
Smith & Nephew plc
2. Name of shareholder having a major interest
Newton Investment Management Ltd
3. Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18
Non-beneficial
4. Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them
Newton Investment Management Ltd
………………………………………………………
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5. Number of shares / amount of stock acquired
6. Percentage of issued class
7. Number of shares / amount of stock disposed
8. Percentage of issued class
9. Class of security
Ordinary shares of US 20 cents
10. Date of transaction
6 April 2010
11. Date company informed
7 April 2010
12. Total holding following this notification
44,329,672
13. Total percentage holding of issued class following this notification
4.99%
14. Any additional information
Holding now below 5%
15. Name of contact and telephone number for queries
Susan Henderson - Company Secretary
020 7401 7646
16. Name and signature of authorised company official responsible for making this notification
Susan Henderson - Company Secretary
Date of notification
7 April 2010