Re Agreement

Stem Cell Sciences plc 23 October 2007 Press Release STEM CELL SCIENCES TO DEVELOP NOVEL MUSCLE STEM CELLS FOR DRUG DISCOVERY AND TOXICOLOGY ("Stem Cell Sciences", "SCS") 23 October 2007 Stem Cell Sciences plc (SCS, AIM:STEM, ASX:STC), the global biotechnology company focused on the commercialisation of stem cells and stem cell technologies in research and cell-based therapies, today announced the signing of an exclusive agreement with San Raffaele Scientific Institute (Milan, Italy) covering assay validation and future commercialisation of novel human muscle stem cells for drug discovery and toxicology applications. Financial terms were not disclosed. These muscle stem cells, a subset of pericytes (cells located around the circumference of small blood vessels), can be extracted from skeletal or heart muscle and retain the capacity to turn into muscle cells on demand. The cells were discovered by Professor Giulio Cossu, Director of the Stem Cells Institute, and his team at the San Raffaele. Pericytes can be readily grown in the laboratory and represent a significant addition to SCS's growing platform of renewable cell types originating from embryonic, neural and adipose stem cell sources. Pericyte-derived muscle cells are believed to be capable of providing the functionality and consistent quality needed for the discovery and testing of new drug candidates on human cells. SCS will initially conduct in-house technology development of the pericytes at its Cambridge, UK, automated cell production facility. Once consistent, automated and cost-effective muscle cell production is confirmed, the technology will be made available to the pharmaceutical industry via a range of commercial options, including assay-ready formats or under license for in-house use. "It's another step for SCS in becoming a leading supplier of stem cells to the pharmaceutical industry," said Dr Peter Mountford, President and CEO of Stem Cell Sciences. "The agreement validates our approach of working with the world's elite stem cell groups. Thanks to our European Union supported "Eurostemcell" collaboration with Professor Cossu, well known for his pioneering work on muscular dystrophy, new and improved approaches to drug discovery and toxicology are now possible." "This is an important result for the San Raffaele Stem Cell Institute. It shows the great potential of stem cell research for a varied range of pharmaceutical applications, including discovery and selection of more effective and safe drugs," commented Daniela Bellomo, Director of the Biotechnology Transfer Centre (BTC) at San Raffaele who negotiated the agreement. Lucia Faccio, Licensing Manager at BTC said: "We are very excited with this agreement and we are confident the development of these assays will quickly proceed thanks to SCS' expertise and word-class facilities." With metabolic diseases such as diabetes, arteriosclerosis and heart failure on the increase, drug companies are actively looking for improved predictive human cell-based assays in the discovery process for new drugs. Cell assays utilising human muscle can more accurately indicate adverse effects of a drug on, for example, normal and regular heart function. Dr Tim Allsopp, SCS' Chief Scientist commented: "The pericytes can be obtained in a very simple manner, grow well in the laboratory and reproducibly make muscle cells, factors which are crucial in building a robust, scalable platform technology." The company intends to provide novel, high quality, functional human skeletal and heart muscle assays to pharmaceutical industry partners. - Ends - For further information, please contact: Stem Cell Sciences plc (United Kingdom) +44 1223 499161 Tim Allsopp, Chief Scientific Officer Halsin Partners +44 207 084 5955 Mike Sinclair Stem Cell Sciences (Australia) pty ltd +61 3 9905 0600 Peter Mountford, President and CEO Talk Biotech +61 422 206036 Fay Weston Stem Cell Sciences llc (USA) +1 415 495 7340 George Murphy, Vice President Business Development Notes to Editors ABOUT STEM CELL SCIENCES: Stem Cell Sciences plc (SCS, AIM: STEM, ASX: STC) is a global biotechnology company providing the biological infrastructure of cells and cell culture media to the burgeoning stem cell research market. Stem Cell Sciences' core objective is to develop safe and effective cell-based therapies for currently incurable diseases. SCS retains all rights to its technology for therapeutic use and is targeting cell-based therapies for neurodegenerative disease and injury. Revenues from Stem Cell Sciences' research business are delivered via an integrated network of business teams and regional offices in Edinburgh and Cambridge (UK), Kobe (Japan), Melbourne (Australia) and San Francisco (USA). This global reach provides the Company with the direct access to markets through experienced personnel and local business networks needed to drive SCS business growth in each region. The key challenge for the successful application of stem cells in both research and clinical applications is the reproducible supply of pure, fully characterized stem cells and stem cell-derived specialised cells such as nerves and muscle. This represents a significant technological challenge that will require access to multiple technologies and a globally integrated stem cell initiative. To access cutting edge technologies on a rapid and on-going basis, Stem Cell Sciences has built an exceptional network of highly interactive collaborations with academic centres of excellence in the stem cell field. These collaborations have been the source of our founding technologies and continue to provide an expanding pipeline of products and intellectual property that are central to the Company's strategy and success. To facilitate research and technology transfer with its major collaborating academic institutions, Stem Cell Sciences' business and scientific teams are usually co-located on site or adjacent to the centre of excellence in independent company facilities. The Company's key collaborating institutes include the Wellcome Trust Centre for Stem Cell Research (University of Cambridge), the Institute of Stem Cell Research (University of Edinburgh), RIKEN Centre for Developmental Biology (Kobe) and the Australian Stem Cell Centre (Melbourne). Academic and commercial use of stem cells in basic research and drug discovery provides the Company with immediate and growing revenue streams and offsets the cost of technology development for full scale cell production of SCS cell-based therapeutics. For further information on the company please visit: www.stemcellsciences.com ABOUT SAN RAFFAELE San Raffaele of Monte Tabor Foundation, founded in 1971 by Luigi Maria Verze, is a non-profit private Foundation characterised by the integration of education with basic research and clinical activities. It includes: the San Raffaele Scientific Institute (550 scientists, 666 publications and an impact factor of 3412 in 2006); the San Raffaele Hospital, one of the biggest hospitals in Italy, with more than 3.600 employees and 1.392 beds, running over 250 clinical trials per year; and The Vita-Salute University. The San Raffaele is active in technology transfer through its Biotechnology Transfer Centre whose mission is to create value from know-how and intellectual property, available within the San Raffaele Scientific Institute. The Biotechnology Transfer Centre acting within Science Park Raf SpA (a company entirely owned by the San Raffaele Foundation) has produced the following results: • 82 international patents filed • 41 patents active • 25 license agreements • 260 sponsored research contracts • 99 industrial clients worldwide (companies that signed research contracts and/or license agreements For further information please visit: www.spr.it and www.sanraffaele.org This information is provided by RNS The company news service from the London Stock Exchange

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