Director/PDMR Shareholding

Fulcrum Pharma PLC
02 August 2006


                               FULCRUM PHARMA PLC

                                ('the Company')

Director Shareholding
The Company was informed on 2nd August 2006 that on 2nd August 2006, Dr Angus
Bell, Non Executive Director of the Company, bought 500,000 ordinary shares in
the Company at 4.0p per share.

As a result, Dr Bell now holds ordinary shares, representing approximately 0.3%
per cent of the current issued share capital of the Company.




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