Holding(s) in Company

Fulcrum Pharma PLC
20 June 2002

                               Fulcrum Pharma Plc

                      ('Fulcrum Pharma' or 'the Company')

Fulcrum Pharma has been advised that Friends Ivory & Sime plc holds a total of
12,065,810 ordinary shares in the Company, which represents 9.90 per cent. of
the issued ordinary share capital of the Company and the shares are held in the
following investment trusts:

                                Number of ordinary shares   Percentage of issued ordinary
                                   held in the Company      share capital of the Company


 Name of Trust                                                                       Name of registered holder

The AIM Tust Plc                                  4,347,826                          3.57 Chase Nominees Limited
AIM VCT 2 Plc                                     3,250,714                          2.67 Chase Nominees Limited
3PC Investment Trust                              4,467,270                          3.66 Chase Nominees Limited
Total                                            12,065,810                          9.90 Chase Nominees Limited



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