Total Voting Rights

Fulcrum Pharma PLC
21 December 2006



                               FULCRUM PHARMA PLC

                              TOTAL VOTING RIGHTS


For the purposes of the transitional provisions of the Financial Services 
Authority's Disclosure and Transparency Rules, the total number of  shares in 
Fulcrum Pharma plc in issue as at the date of this notice is as follows:

Class      Nominal Value per share    Number in issue   Voting rights attached
Ordinary                        1p        128,528,987              128,528,987

The Company does not hold any shares in treasury.

The above figure may be used by shareholders as the denominator for the 
calculations by which they will determine if they are required to notify their
interest in, or a change to their interest in, Fulcrum Pharma plc under the 
Disclosure and Transparency Rules.

End



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