Oxford Asymmetry

Director Shareholding

Oxford Asymmetry International PLC
23 October 2000

                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

   OXFORD ASYMMETRY INTERNATIONAL PLC


2)  NAME OF DIRECTOR

    M.E.C. POLYWKA

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    DIRECTOR

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)



5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary


    EXERCISE OF SHARE OPTIONS 
    ACCEPTANCE OF EVOTEC BIOSYSTEMS AG OFFER

7)  Number of shares/amount of
    stock acquired

    197,467

8)   (0.004 %)
    of issued Class


9)  Number of shares/amount
    
    197 467   Shares converted to Evotec Shares on acceptance of Offer


10)  (  %)
    of issued Class

    SHARES CONVERTED TO EVOTEC SHARES ON ACCEPTANCE OF OFFER

11) Class of security

    10P ORD


12) Price per share

    143,765 @ £1.252
     38,244 @ £4.445
     15,458 @ £5.175

13) Date of transaction

    16.10.00

14) Date company informed

    18.10.00

15) Total holding following this notification

    NIL

16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant



18) Period during which or date on which exercisable



19) Total amount paid (if any) for grant of the option



20) Description of shares or debentures involved: class, number.



21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise



22) Total number of shares or debentures over which options held
    following this notification



23) Any additional information



24) Name of contact and telephone number for queries

    DAVID RICHARDSON
    01235 861561

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification  23 OCT 2000




                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

   OXFORD ASYMMETRY INTERNATIONAL PLC


2)  NAME OF DIRECTOR

    M.E. HAY

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    DIRECTOR

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)



5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary


    EXERCISE OF SHARE OPTIONS & 
    ACCEPTANCE OF EVOTEC BIOSYSTEMS AG OFFER

7)  Number of shares/amount of
    stock acquired

    224,860

8)   (0.005 %)
    of issued Class


9)  Number of shares/amount
    
    224,860      Shares converted to Evotec Shares on acceptance of offer


10)  (  %)
    of issued Class

    SHARES CONVERTED TO EVOTEC SHARES ON ACCEPTANCE OF OFFER

11) Class of security

    10P ORD


12) Price per share

    183705 @ £1.252
     31494 @ £4.445
      9661 @ £5.175

13) Date of transaction

    16.10.2000

14) Date company informed

    18.10.2000

15) Total holding following this notification

    7,985

16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant



18) Period during which or date on which exercisable



19) Total amount paid (if any) for grant of the option



20) Description of shares or debentures involved: class, number.



21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise



22) Total number of shares or debentures over which options held
    following this notification



23) Any additional information



24) Name of contact and telephone number for queries

    DAVID RICHARDSON
    01235 861561

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification  23 OCT 2000




                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

    OXFORD ASYMMETRY INTERNATIONAL PLC


2)  NAME OF DIRECTOR

    M.E. HAY

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    DIRECTOR

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

    MRS N HAY

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary


    EXERCISE OF SHARE OPTIONS 
    FOLLOWED BY SPOUSE TRANSFER

7)  Number of shares/amount of
    stock acquired

    7,985

8)   (- %)
    of issued Class


9)  Number of shares/amount
    
    


10)  (  %)
    of issued Class

    

11) Class of security

    10P ORD


12) Price per share

     £1.252
    
13) Date of transaction

    11.10.2000

14) Date company informed

    11.10.2000

15) Total holding following this notification

    7,985

16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant



18) Period during which or date on which exercisable



19) Total amount paid (if any) for grant of the option



20) Description of shares or debentures involved: class, number.



21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise



22) Total number of shares or debentures over which options held
    following this notification



23) Any additional information



24) Name of contact and telephone number for queries

    DAVID RICHARDSON
    01235 861561

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification  23 OCT 2000





                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

    OXFORD ASYMMETRY INTERNATIONAL PLC


2)  NAME OF DIRECTOR

    E. MOSES

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    DIRECTOR

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)



5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)

    N/A

6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary


    EXERCISE OF SHARE OPTIONS 
    ACCEPTANCE OF EVOTEC BIOSYSTEMS AG OFFER

7)  Number of shares/amount of
    stock acquired

    191,270

8)   (0.004 %)
    of issued Class


9)  Number of shares/amount
    
    191,270      Shares converted to Evotec shares on acceptance of offer


10)  (  %)
    of issued Class

    SHARES CONVERTED TO EVOTEC SHARES ON ACCEPTANCE OF OFFER

11) Class of security

    10P ORDS


12) Price per share

    79,870 @ £1.252
    91,112 @ £4.445
    20,288 @ £5.175

13) Date of transaction

    16.10.2000

14) Date company informed

    18.10.2000

15) Total holding following this notification

    NIL

16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant



18) Period during which or date on which exercisable



19) Total amount paid (if any) for grant of the option



20) Description of shares or debentures involved: class, number.



21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise



22) Total number of shares or debentures over which options held
    following this notification



23) Any additional information



24) Name of contact and telephone number for queries

    DAVID RICHARDSON
    01235 861561

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification  23 OCT 2000